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KMID : 0882420100780030325
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Korean Journal of Medicine
2010 Volume.78 No. 3 p.325 ~ p.332
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The effects of statins on electrical stability in patients with essential hypertension
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Kim Sung-Soo
Jang Soo-Young
Ko Jum-Suk
Yoon Nam-Sik
Kim Kye-Hun
Park Hyung-Wook
Hong Young-Joon
Kim Ju-Han
Ahn Young-Keun
Jeong Myung-Ho
Cho Jeong-Gwan
Park Jong-Chun
Kang Jung-Chaee
Cho Sang-Ki
Lee Seung-Wook
Kim Wan
Kim Nam-Ho
Rhew Jay-Young
Cho Jang-Hyun
Jeong Joong-Wha
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Abstract
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Background/Aims: Essential hypertension is the most common cardiovascular disease and is involved in the development of the various cardiac arrhythmias, including atrial fibrillation. Recently, several studies have shown that statins have anti-arrhythmic effects, including the prevention of atrial fibrillation. This study investigated the effects of statins on cardiac electrophysiologic remodeling in patients with essential hypertension using the signal-averaged electrocardiogram (ECG) and standard 12-lead ECG.
Methods: This prospective multicenter study enrolled 115 patients with hypertension. Various antihypertensive drugs were administered alone or in combination according to their blood pressure. Statins were administrated in 56 patients. Laboratory tests, a standard 12-lead ECG, and signal-averaged ECG were performed at 1, 3, 6, and 12 months. Statistical analysis was performed using paired and independent t-tests and repeated measures analysis of variance (ANOVA).
Results: There was no significant difference in the clinical characteristics of the patients with and without statins. After antihypertensive therapy for 1 year, the P wave dispersion, high-frequency low-amplitude (HFLA) signals in the QRS complex of less than 40 μV, and T peak-to-end dispersion were increased significantly (p<0.001, p<0.05, and p<0.01, respectively) in the patients who were not taking statins, while these changes were not seen in the statin group.
Conclusions: These results demonstrate that electrophysiologic remodeling was progressive in patients with essential hypertension, despite antihypertensive therapy. However, combination therapy with a statin may inhibit the deterioration of inhomogeneity in atrial refractoriness and conduction disturbance.
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KEYWORD
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Hypertension, Statin, Electrophysiology
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